Selected Publications - The Laboratory of Tanya Mayadas, Ph.D.

21. Utomo A, Cullere X, Glogauer M, Swat W, Mayadas TN. Vav proteins in neutrophils are required for FcgammaR-mediated signaling to Rac GTPases and nicotinamide adenine dinucleotide phosphate oxidase component p40(phox). J Immunol. 2006 Nov 1;177(9):6388-97.

20. Hirahashi J, Mekala D, Van Ziffle J, Xiao L, Saffaripour S, Wagner DD, Shapiro SD, Lowell C, Mayadas TN. Mac-1 Signaling via Src-Family and Syk Kinases Results in Elastase-Dependent Thrombohemorrhagic Vasculopathy. Immunity. 2006 Aug;25(2):271-83. Epub 2006 Jul 27.

19. Liu Z, Zhao M, Li N, Diaz LA, Mayadas TN. Differential roles for beta2 integrins in experimental autoimmune bullous pemphigoid. Blood. 2006 Feb 1;107(3):1063-9.

18. Vielhauer V, Stavrakis G, Mayadas TN. Renal cell-expressed TNF receptor 2, not receptor 1, is essential for the development of glomerulonephritis. J Clin Invest. 2005 May;115(5):1199-209.

17. Cullere X, Shaw SK, Andersson L, Hirahashi J, Luscinskas FW, Mayadas TN. Regulation of vascular endothelial barrier function by Epac, a cAMP-activated exchange factor for Rap GTPase. Blood. 2005 Mar 1;105(5):1950-5. Epub 2004 Sep 16.

16. Stokol T, O'Donnell P, Xiao L, Knight S, Stavrakis G, Botto M, von Andrian UH, Mayadas TN. C1q governs deposition of circulating immune complexes and leukocyte Fcgamma receptors mediate subsequent neutrophil recruitment. J Exp Med. 2004 Oct 4;200(7):835-46.

15. Zhang B, Hirahashi J, Cullere X, Mayadas TN. Elucidation of molecular events leading to neutrophil apoptosis following phagocytosis: cross-talk between caspase 8, reactive oxygen species, and MAPK/ERK activation. J Biol Chem. 2003 Aug 1;278(31):28443-54. Epub 2003 May 07.

14. Sethi S, Ziouzenkova O, Ni H, Wagner DD, Plutzky J, Mayadas TN. Oxidized omega-3 fatty acids in fish oil inhibit leukocyte-endothelial interactions through activation of PPARalpha. Blood 2002 Aug 15;100(4):1340-6.

13. Coxon A, Cullere X, Knight S, Sethi S, Wakelin MW, Luscinskas FW, Mayadas TN. Fc RIII mediates neutrophil recruitment to immune complexes: A mechanism for neutrophil accumulation in immune-mediated inflammation. Immunity 2001;14: 693-704.

12. van Spriel AB, Leusen JH, van Egmond M, Dijkman HB, Assmann KJ, Mayadas TN, van de Winkel JG. Mac-1 (CD11b/CD18) is essential for Fc receptor-mediated neutrophil cytotoxicity and immunologic synapse formation. Blood 2001; 97: 2478-86

11. Barkalow FJ, Barkalow K, and Mayadas TN. Dimerization of P-selectin in platelets and endothelial cells. Blood 2000; 96:3070-7.

10. Rosenkranz AR, Knight S, Sethi S, A Alexander SI, Cotran RS, Mayadas TN. Regulatory interactions of alphabeta and gammadelta T cells in glomerulonephritis. Kidney Int. 2000; 58:1055-1066.

9. Coxon AC, Tang TT, Mayadas TN. Cytokine activated endothelial cells delay apoptosis both in vitro and in vivo: a role for endothelial derived granulocyte-macrophage colony stimulating factor. J. Exp. Med: 1999; 190:923-34.

8. Rosenkranz AR, Mendrick DL, Cotran RS, Mayadas TN. P-selectin deficiency exacerbates experimental glomerulonephritis: A protective role for endothelial P-selectin in inflammation. J. Clin. Invest: 1999; 103:649-659.

7. Soriano SG, Coxon A, Wang YF, Frosch MP, Hickey PR, Mayadas TN. Mice deficient in Mac-1 (CD11b/CD18) are less susceptible to cerebral ischemia-reperfusion injury. Stroke: 1999; 30: 134-139.

6. Rosenkranz AR, Coxon A, Maurer M, Gurish MF, Austen KF, Friend DS, Galli SJ, Mayadas TN. Impaired mast cell development and innate immunity in Mac-1 (CD11b/CD18, CR3)-deficient mice. J. Immunol. 1998; 161:6463-67

5. Tang TT, Rosenkranz A, Assmann KJM, Goodman MJ, Gutierrez-Ramos J-C, Carroll MC, Cotran RS, Mayadas TN. A role for Mac-1 (CD11b/CD18) in Fcgamma R interactions in vivo: Mac-1 deficiency abrogates sustained neutrophil adhesion and proteinuria in Fc-dependent anti-glomerular basement membrane nephritis. J. Exp. Med: 1997; 186:1853-1863.

4. Coxon A, Barkalow FJ, Askari S, Rieu P, Sharpe AH, von-Andrian UH, Arnaout MA, Mayadas TN. A novel role for the beta2 integrin, CD11b/CD18, in neutrophil apoptosis: A homeostatic mechanism in inflammation. Immunity: 1996; 5:653-666

3. Tang T, Frenette PS, Hynes RO, Wagner DD, Mayadas TN. Response to cytokine-induced meningitis is dramatically attenuated in mice deficient in endothelial selectins. J. Clin. Invest. 1996; 97:2485-2490

2. Frenette PS, Mayadas TN, Rayburn H, Hynes RO, Wagner DD. Leukocyte adhesion defects, altered hematopoiesis and susceptibility to infection in P- and E-selectin deficient mice. Cell 1996; 84:563-574

1. Mayadas TN, Johnson RC, Rayburn H, Hynes RO, Wagner DD. Leukocyte rolling and extravasation are severely compromised in P-selectin-deficient mice. Cell 1993; 74:541-554